https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34787 Wed 19 Jan 2022 15:18:05 AEDT ]]> Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1β https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27569 Wed 11 Apr 2018 11:56:33 AEST ]]> Reduced antiviral interferon production in poorly controlled asthma is associated with neutrophilic inflammation and high-dose inhaled corticosteroids https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26090 Wed 02 Mar 2022 14:26:24 AEDT ]]> Efficacy of azithromycin in severe asthma from the AMAZES randomised trial https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37078 Tue 29 Sep 2020 11:48:51 AEST ]]> Severe asthma: current management, targeted therapies and future directions-a roundtable report https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33751 Tue 08 Jan 2019 15:37:34 AEDT ]]> A sputum 6-gene signature predicts future exacerbations of poorly controlled asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36051 Thu 28 Oct 2021 13:04:53 AEDT ]]> Airway dysbiosis: Haemophilus influenza and Tropheryma in poorly controlled asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24324 Tropheryma whipplei and Haemophilus influenzae in sputum. Adults with neutrophilic asthma had reduced bacterial diversity and species richness. Tropheryma was identified and confirmed with real-time PCR in 12 (40%) participants. Haemophilus occurred most often in a group of younger atopic males with an increased proportion of neutrophils. PCR confirmed the presence of H. influenzae in 35 (76%) participants with poorly controlled asthma. There are phenotype-specific alterations to the airway microbiome in asthma. Reduced bacterial diversity combined with a high prevalence of H. influenzae was observed in neutrophilic asthma, whereas eosinophilic asthma had abundant T. whipplei.]]> Thu 28 Oct 2021 13:02:17 AEDT ]]> Severe asthma assessment, management and the organisation of care in Australia and New Zealand: expert forum roundtable meetings https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39023 Thu 21 Apr 2022 09:51:00 AEST ]]> Periostin levels and eosinophilic inflammation in poorly-controlled asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24852 Thu 17 Feb 2022 09:28:28 AEDT ]]> Sputum TNF markers are increased in neutrophilic and severe asthma and are reduced by azithromycin treatment https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49306 Thu 11 May 2023 14:32:33 AEST ]]> Long-Term Azithromycin reduces haemophilus influenzae and increases antibiotic resistance in severe asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47850 Thu 02 Feb 2023 16:46:49 AEDT ]]> Genome-wide association analysis identifies six new loci associated with forced vital capacity https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21233 P < 5 × 10−8) with FVC in or near EFEMP1, BMP6, MIR129-2–HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.]]> Sat 24 Mar 2018 07:53:01 AEDT ]]> Severe asthma toolkit: an online resource for multidisciplinary health professionals–needs assessment, development process and user analytics with survey feedback https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40572 Mon 08 Aug 2022 15:11:18 AEST ]]> Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33089 Fri 24 Aug 2018 16:46:54 AEST ]]> The cost-effectiveness of azithromycin in reducing exacerbations in uncontrolled asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46066 Fri 11 Nov 2022 14:45:17 AEDT ]]>